First ‘clear evidence’ of hallucinogens at cave art site found
Research indicates rock painting represents the plant itself, serving to codify communal rituals
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Londoners toast return to Tier Two on December 2 while those in Manchester fume over strictest curbs
Pub-starved Londoners have today toasted a return to Tier Two on December 2, while those in Manchester have been left fuming over facing tough Tier Three restrictions.
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New Covid tier system branded ‘authoritarian’ by influential Tory as backbench revolt looms
Steve Baker repeats call for publication of analysis of health and economic impacts of restrictions
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Coronavirus restrictions mapped: Which tier is your area in?
Most of country faces tougher rules than before lockdown
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EastEnders star Danny Dyer brands fitness guru Joe Wicks ‘f****** irritating’
He didn't mince his words about 'fitness freaks'.
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Full list of Premier League clubs that can let fans in again
Fans can return to football stadiums once again in December.
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Jack Wilshere opens up on his West Ham career, early exit and Manuel Pellegrini ‘disagreement’
Jack Wilshere has opened up on his struggles to make an impact during his disastrous spell at West Ham, and revealed a falling out with former manager Manuel Pellegrini.
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Guided by the science? This Covid tier system is about as scientific as Baby Yoda’s telekinesis powers
The new tiers are arbitrary and confusing – this is fast turning into one of those very British exercises in nonsense
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Zebrafish to help identify genes that cause scarring
Five-year project will study the translucent tropical fish that originates from Southeast Asia
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Football Digest: Diego Maradona tributes, Champions League and Premier League
The Football Digest panel return for another episode to talk you through this week in football. Top of the agenda this week, of course, is the death of Diego Maradona
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Owen slams Liverpool's 'worst display in a long time' in defeat to Atalanta
Liverpool still lead their Champions League Group D by two points but are now under pressure to get a result against Ajax next week while Atalanta can gain further ground
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Severe cold weather alert issued by Met Office as icy blast poses danger to life
A polar blast is bringing some of the chilliest days of the season along with freezing fog, and the Met Office has raised its severe cold weather alert to level 2
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I’m A Celebrity 2020: Shane Richie’s son calls AJ Pritchard ‘a little b***h’ over cleaning dig
Drama over the dishes.
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Tier 2: City of London says clarity on when office workers can return needed
City of London Corporation policy chair Catherine McGuinness, says: “A blanket recommendation to work from home into the Spring risks stalling the capital’s recovery and damaging long-term competitiveness."
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EU fines drug makers for keeping cheap medicine off market
The European Union has fined two pharmaceutical companies for colluding to keep a cheap alternative to a sleep disorder medicine off the market for their profit and at the expense of patients
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Veteran BBC journalist and his boyfriend are found dead
John Stevenson, 68, who broadcast many stories from Westminster including the response to the 9/11 attacks, was found at his home in Aberdare, South Wales.
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Explained: The Row About Oxford's Coronavirus Vaccine Trial Results
Oxford University and AstraZeneca have acknowledged a manufacturing error meant some trial participants received only a partial dose of their experimental Covid-19 vaccine.The announcement has raised questions about why researchers did not mention the error when they claimed the jab was “highly effective” just days ago.It has also raised some concerns about the part of the study which showed a 90% success rate. Oxford and AstraZeneca have since addressed these issues and explained the next steps for the jab, to ensure its safety and effectiveness. Here is what we know: The studyOn Monday, Oxford and AstraZeneca announced preliminary results from trials showed an average efficacy of 70% – a figure reached by pooling the results from two different dosing regimens.One month apart, one set of volunteers received two identical doses while the other received a half-dose, and then a full dose. In the first group, the efficacy was 62%. In the second, 90%.The results were hailed a success, but it has since been revealed that some volunteers were only given a half dose because some of the vials did not have the right concentration of vaccine.Mene Pangalos, R&D lead at AstraZeneca, admitted to this dosing error to Reuters on Monday. The manufacturing error was only caught when some of the people in the study did not show the usual adverse effects. Oxford has said it discussed the problem with regulators and completed the late-stage trial with two groups.The second subgroup – the one that had a 90% efficacy – was also limited to participants aged 55 and below. In a statement on Wednesday, Oxford acknowledged a difference in manufacturing and measurement processes meant later phases of its clinical studies resulted in half a dose being administered instead of a full one. “The methods for measuring the concentration are now established and we can ensure that all batches of vaccine are now equivalent,” it said.What this could meanSome parts of the scientific community have responded to the news with confusion and discontent, with Oxford and AstraZeneca coming under fire for lack of transparency. Experts have said the relatively small number of people in the low dose group – 2,741 compared to the 8,895 people who received two full doses – means it is difficult to know if that average efficacy is accurate.The fact that the low-dose group were all aged 55 and under has also sent alarm bells ringing. Younger people are generally at a lower risk of developing severe Covid-19, so the results of the group could merely reflect this stronger immune response.This is a particularly significant problem because many people on the list of groups to be prioritised to receive a Covid-19 vaccine would fall into the category of over the age of 55. Experts have also highlighted the fact that the results of the Oxford vaccine trials came out of two separate studies: one in the UK and one in Brazil. In the UK, participants who were not given the vaccine were administered a meningococcal vaccine. In Brazil, the equivalent group was administered a saline placebo.The variation in “control” injections in volunteers has led to concerns that the data is not standardised and cannot be combined into a single efficacy result.Experts have said this error – as well as some other irregularities - have damaged confidence in the reliability of the results.  “We just don’t have all the information we need to tell whether these results are reliable,” Natalie Dean, an assistant professor of biostatistics at the University of Florida, told the Financial Times.“We certainly don’t have enough information in the public domain to decide whether this half dose is really working.”Another point of confusion comes from a decision to pool the results to reach an average 70% effectiveness, said David Salisbury, and associate fellow of the global health program at the Chatham House think tank.“You’ve taken two studies for which different doses were used and come up with a composite that doesn’t represent either of the doses,” he told Associated Press. “I think many people are having trouble with that.”By combining two separate trials into one combined data, Oxford/AstraZeneca could be indicating results from each were not clear enough to release on their own, Wired magazine reported, calling the incident a “scientific red flag with flashing lights”.This could also mean the Oxford vaccine might not receive regulatory approval as soon as hoped.John LaMattina, a former president of Pfizer’s global R&D unit, said it would be hard to believe regulators in the US would issue an emergency-use authorisation for the vaccine.Hard to believe that the FDA will issue an EUA for a vaccine whose optimal dose has only been given to 2,300 people. More data for this dosing regiment will be needed. https://t.co/WfxYkGNCXu— John LaMattina (@John_LaMattina) November 24, 2020What have Oxford and AstraZeneca said?A spokesperson from AstraZeneca said the trials were “conducted to the highest standards” and met their primary efficacy endpoint.Details of the trial results will be published in peer-reviewed journals and provided to UK regulators. These will provide a more complete picture of how effective the vaccine really is, and help regulators decide whether to authorise its distribution. When reached for comment, a spokesperson from Oxford University said: “During the phase III trials, our UK study used two dose levels.“The initial dose selection, which was agreed with regulators, was based on the same measurement of the concentration (using spectrophotometry) used in the phase I study, but, as a result of a difference in the manufacturing process for the later study, this method was subsequently shown to over-estimate the dose on the new batches of vaccine resulting in a half dose of the vaccine being administered as the first dose.“We have different ways of measuring the concentration of the vaccine and when it was apparent that a lower dose was used, we discussed this with the regulator, and agreed a plan to test both the lower dose/higher dose and higher dose/higher dose, allowing us to include both approaches in the phase III trial.“The methods for measuring the concentration are now established and we can ensure that all batches of vaccine are now equivalent.”What about the other vaccines?The Moderna and Pfizer/BioNTech experimental vaccines only involved single trials and released trial protocols weeks ahead of time for expert scrutiny. But neither of the jabs have been tested for whether they break transmission of Covid-19, only for whether they stop people from developing Covid-19 symptoms or testing positive. Despite this recent news, the Oxford vaccine is still the best hope for many countries as it is cheaper than the mRNA vaccines and can be stored in a refrigerator instead of a freezer. It is also the UK’s best chance for mass vaccination by the end of spring, as the government has already ordered 100 million doses to vaccinate 50 million people. Related... Why We Will Still Need Mass Testing Even When There's A Vaccine What The Scientists Are Saying About Boris Johnson’s Christmas Bubbles Plan Opinion: I'm An NHS Doctor. Boris Johnson's Christmas Plans Are Deadly
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Czech police on the hunt for rifle stolen by deer
“The deer was startled by a dog and charged straight towards a member of a party of hunters”
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Gareth Southgate reveals Chris Coleman inspiration over accepting England job
Gareth Southgate has revealed he initially rejected the England job because of the pain of Euro '96 but was inspired to change his mind by former Wales manager Chris Coleman.
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The only Tier 1 areas in England - and the rules
The government has announced which areas of England will be placed into Tier 1, 2 or 3 from next week
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Hotel concierge who 'helped £50,000 Lampard burglary gang' says he thought 'thieves' were migrants
A hotel concierge who has denied helping burglars raid Frank Lampard's home said he thought they were migrants hoping to build a better life in the UK.
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The Crown season 4 ‘watched by more people than Charles and Diana’s actual wedding’
That's a hell of a lot of people!
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Miracle as girl, 10, reunited with pet cat 9 months after it first went missing
Mum Svitlana was able to capture the long-awaited moment that her daughter was reunited with her cat, thanks to the staff at Cat Protection who managed to track him down
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US Billionaires Grow Wealth By Over $1 Trillion Since Coronavirus Pandemic Began, Says Report
Billionaires in the US have grown their wealth by over a third — or by more than $1 trillion — since the Covid-19 pandemic hit the nation in March, a new report finds. At the same time, the economic crisis caused by the coronavirus pandemic has left millions of Americans jobless and struggling to pay their mortgages, rents and food bills. A report released Wednesday by the Washington-based Institute for Policy Studies tracked the net worth of the over 650 of the wealthiest Americans from March 18 to November 24, and found that dozens joined the ranks of billionaires during this period and that 29 saw their wealth double amid the pandemic.The net worth of this minuscule group is twice the amount of wealth of the bottom 50% of US households — about 160 million people, per the report. Billionaires have hit a disturbing milestone:ONE TRILLION DOLLARS in wealth gains during the pandemic.https://t.co/Za4TttVtl8pic.twitter.com/Qqr6A3Duqd— Inequality.org (@inequalityorg) November 25, 2020Amazon’s Jeff Bezos saw his net worth grow 61% since mid-March, from $113 billion to $182.4 billion. Amazon’s workers, meanwhile, haven’t received hazard pay in months, even as they’ve continued working during the worsening pandemic. Nearly 20,000 Amazon workers have been infected with coronavirus, according to the company. An Amazon spokesperson told HuffPost that “nothing is more important than the health and safety of our employees,” adding that the company pays workers at least $15 per hour and has provided masks and gloves, as well as on-site Covid-19 testing in certain locations.Bezos is one of five “centi-billionaires” in the world — people with a net worth over $100 billion — alongside Louis Vuitton chairman Bernard Arnault, Microsoft founder Bill Gates, Facebook CEO Mark Zuckerberg, and Tesla CEO Elon Musk. Three years ago, there were no centi-billionaires, according to the report. The US unemployment rate was nearly 7% last month — with over 11 million Americans considered unemployed — nearly twice the level of February, before the pandemic hit.The US Census Bureau’s survey of American households found that from October 28-November 9, over 15 million households — or 28% of renters surveyed — had either “no confidence” or only “slight confidence” of being able to make their next month’s payment.Related... Joe Biden Defends His Cabinet Choices: 'This Is Not A Third Obama Term' 'A Total Disgrace': Washington Post Editorial Board Tears Into Trump Trump Phones In To Hearing In Bizarre Act Of Desperation
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Pubs to stay shut in many areas in new English virus curbs
Most people in England will continue to face tight restrictions on socializing and business after a nationwide lockdown ends next week
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'My sister's choice of baby name is a massive mistake but she won't listen'
A woman has said her sister is "refusing to acknowledge my existence" after she told her the baby name she had picked for her son would lead him being bullied as he grows up
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Manchester United have simple Daniel James decision to make
Wales international Daniel James shone for Man Utd in their Champions League win over Istanbul Basaksehir on Tuesday night.
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LIVE: Woman on trial accused of murdering seven-year-old Emily Jones
Eltiona Skana is standing trial at Manchester Minshull Street Crown Court
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Matt Hancock in thinly veiled swipe at Andy Burnham as Manchester goes into Tier 3
MATT HANCOCK delivered a thinly veiled swipe at Greater Manchester Mayor Andy Burnham after it was announced the county would go into Tier 3 restrictions at the end of the national lockdown.
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Devastated dad who lost wife to cancer wins £1,000,000 house in £10 charity draw
The father-of-three said it was the 'boost' he and his sons desperately needed after losing wife Julie.
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Corrie's Bruce Jones tried to kill himself after seeing Yorkshire Ripper victim
Coronation Street star Bruce Jones remembered taking an overdose after discovering the Yorkshire Ripper victim led to haunting nightmares
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Microsoft admits some PS5 games run better than Xbox Series X – says it won’t last
The Xbox Series X is supposed to be the most powerful console in the world, so how comes so many multiformat PS5 game run better?
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This Morning viewers slam mother-of-one who reveals she plans to see grandparents at Christmas
This Morning viewers slammed Lora Evans, 33, from Swansea, who appeared on the programme today to reveal she plans to see her elderly relatives this Christmas.
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All the rules for pubs, cafés, bars and restaurants in Tiers 1, 2 and 3
England faces new tiered restrictions from December 2, with London in Tier 2 and Manchester set to enter the highest level next week - here's what it means for the hospitality sector
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Can you travel from Tier 3 to Tier 2?
TIER levels assigned by the Government released today, as Matt Hancock delivered a statement in Parliament informing MPs which regions would receive the most restrictive measures. Can you travel from Tier three to Tier two?
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'Manchester would not be in tier 3 if schools had closed in lockdown'
Including schools in the national lockdown would have pushed cases down further, he says
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Youthful Hong Kong actress, 54, is 'amazed' she can still fit into a middle-school uniform
Age-defying star Carman Lee has expressed her amazement to MailOnline after fitting into the schoolwear aged 54. Pictures show her looking like her 17-year-old self while sporting the dress.
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Number of EU nationals working in the UK has plunged by 16 per cent since start of pandemic
The number of EU nationals working in the UK has plunged by 16 per cent since the start of the coronavirus pandemic, official figures revealed today.
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Bill Turnbull, 64, emotionally urges men to get prostate exams amid his terminal cancer battle
Bill Turnbull has emotionally urged men to go for prostate exams amid his battle with terminal cancer.
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Alexander Thorne's 21-day ban to stand as BHA dismiss appeal
The conditional jockey missed out the scales after winning a race and being interviewed by ITV. Racecourses are laid out differently due to Covid-19 rules
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Fuller’s boss blasts tiers system that ‘singles out’ pubs as sector warns of ‘looming disaster’
Pub giants Fuller's and Mitchells & Butlers revealed they had plunged to multimillion pound losses on Thursday amid warnings the industry faces "looming disaster" with many pubs and breweries at risk of permanent closure.
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Wales identifies 200 statues, roads and buildings with 'links to the slave trade'
The review was ordered by Welsh First Minister Mark Drakeford following the death of George Floyd in the US and the toppling of the statue of Edward Colston in Bristol.
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London pub and restaurant owners react to announcement of Tier 2 restrictions, as ‘wet led’ businesses cry out for help
London business leaders today said they were relieved to have been spared Tier 3 — but were counting the cost of  a four-week lockdown that has hit the capital’s economy for an estimated  £6 billion.
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A festive maze and a giant marmot: Thursday's best photos
The Guardian’s picture editors select photo highlights from around the world Continue reading...
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Mike Tyson knocked sparring partner's tooth out ahead of Roy Jones Jr fight
Tyson returns to the ring for the first time in 15 years when he takes on Jones Jr in a so-called exhibition fight on Saturday
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Angry tradesman tears down building work ‘after not being paid’
Footage posted on TikTok shows the worker standing on scaffolding, using a hammer to tear pieces off the side of the building.
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Which Premier League clubs can have fans in stadiums? How tiers affect each club
Half of the Premier League's clubs will have to continue their games behind closed doors this season after the government announced which tiers different areas will be placed in.
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Hope for Hammersmith bridge with plans for ‘double decker’ temporary crossing
Crossing could reopen with traffic on upper level and pedestrians below
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